HAEMATOLOGY/ONCOLOGY MCQs pdf free download. Q-1
Which electrolyte disturbance is cisplatin most associated with?
A. Hypocalcaemia
B. Hyponatraemia
C. Hypomagnesaemia
D. Hypokalaemia
E. Hypercalcaemia
ANSWER:
Hypomagnesaemia
EXPLANATION:
Cisplatin is associated with hypomagnesaemia
CYTOTOXIC AGENTS
The tables below summarises the mechanism of action and major adverse effects of commonly used cytotoxic agents.
Alkylating agents Cytotoxic Mechanism of action Adverse effects Cyclophosphamide Alkylating agent – causes cross-linking in DNA Haemorrhagic cystitis, myelosuppression, transitional cell carcinoma
Cytotoxic antibodies Cytotoxic Mechanism of action Adverse effects Bleomycin Degrades preformed DNA Lung fibrosis Doxorubicin Stabilizes DNA-topoisomerase II complex inhibits DNA & RNA synthesis Cardiomyopathy
HAEMATOLOGY/ONCOLOGY MCQs pdf free download
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